SynthID Bio: Watermarking methods for synthetic biology

SynthID Bio adapts watermarking techniques for synthetic biology, specifically for AI-generated proteins. It embeds signatures into protein sequences by subtly guiding amino acid choices and into 3D structures by adjusting atomic coordinates. The method was validated on protein binders using AlphaProteo and ProteinMPNN, showing no compromise in functional metrics. For protein folding, SynthID Bio fine-tunes AlphaFold 3's diffusion network to embed watermarks directly into model weights, preserving prediction accuracy and structural features. The post details the technical approach for both sequence and structure watermarking, including experimental validation in wet-lab testing.