Run NVIDIA BioNeMo NIM Microservices for Protein Structure Prediction in Claude Science | NVIDIA Technical Blog

This post details the integration of the NVIDIA BioNeMo Agent Toolkit with Claude Science, enabling AI agents to orchestrate protein structure prediction workflows. It demonstrates the use of NIM microservices for MSA generation (MSA Search NIM) and protein folding (OpenFold3 NIM, Boltz-2 NIM). The post outlines the setup process, including connecting to compute endpoints and launching local NIM containers, and provides specific prompts for generating MSAs and performing structure predictions for both monomer and heteromer cases. It highlights the importance of MSA input for accurate interface prediction and presents a comparative analysis of OpenFold3 and Boltz-2 predictions.